Matthew Fountain

Matthew Fountain


Matthew Fountain

Office Location

 8255 Scott Hall

Position Title

Fourth year student in the Ph.D. program.


B.S. in Nutritional Science from Michigan State University, 2011
M.S. in Immunology/Microbiology from Wayne State University, 2015

Research Interests

My research interests include mechanisms of cell death, innate immunology and immunopathology, cell signaling, vascular biology, radiation biology, and immunological-based therapies and drug discovery. Our lab studies normal tissue injury as a result of ionizing irradiation. We are interested in the radiobiological responses in tumor cells and normal cells, the radiation-induced inflammatory responses as it relates to acute radiation injury and the development of radiation fibrosis, and the radioprotection of normal tissues by natural compounds during radiotherapy.

My project is focused on the mechanisms of isoflavones to mediate radiation-induced normal tissue injury and the inflammatory response to thoracic tissues and vasculature of the lungs, heart, and esophagus. We have shown in each of these irradiated tissues that isoflavones provide a radioprotective effect histologically with reduced inflammation and fibrosis. Specifically, I am identifying inflammatory cytokines and DAMPs released by epithelium and vascular endothelium and smooth muscle that are collectively responsible for initiating and perpetuating the chronic inflammatory response after ionizing irradiation. My hypothesis is that our isoflavone compound modifies the profile of these molecules released upon radiation injury, and thereby redirects the inflammatory response leading to the healthy phenotype that we have observed in-vivo.

Advisor: Dr. Gilda Hillman