Department of Immunology and Microbiology

Profile

Paul Montgomery
Title
Professor
Phone
(313) 577-9339
Biography

Paul C. Montgomery, Ph.D., is professor of Immunology and Microbiology. He came to the School of Medicine in 1983 from the University of Pennsylvania where he was Professor of Microbiology and Chairman of the Immunology Graduate Group. Dr. Montgomery received his Ph.D. from the University of Pennsylvania in 1969 and was a postdoctoral fellow at the National Institute for Medical Research, London. He is the former recipient of a Fogarty Senior International Fellowship and was a visiting professor in the Department of Experimental Medicine at the University of Louvain in Brussels.

Dr. Montgomery's current research interests include: immunochemical and cellular aspects of immunity at mucosal surfaces; molecular properties of secretory IgA; mechanisms controlling IgA antibody responses; and the immunobiology of the eye. His laboratory has documented that the lacrimal compartment of the eye is linked to the common mucosal immune system by the selective migration of IgA-bearing lymphocyte populations. This linkage has significance in the development of appropriate delivery schemes for potential vaccine agents useful in preventing ocular disease. Ongoing work is directed at answering the following questions:

1. Can cytokines be employed to effectively regulate secretory IgA antibody responses?
2. What is the regulatory role of anti-idiotypic antibodies in mucosal responses?
3. How does intranasal antigen administration stimulate IgA antibody induction in tears and saliva?
4. What role do lymphocyte subsets and cell traffic mechanisms play in mucosal-associated immune responses?
5. What are the mechanistic events and molecular interactions governing lymphocyte localization in mucosal tissues?
6. Do mucosal-associated responses play a role in protection and/or pathogenesis following exposure to infectious agents?
7. What is the role of the dendritic cell in mucosal immune responses?

These investigations, in the rat model, utilize biochemical, immunological and molecular approaches together with cell and tissue culture systems, adherence and motility assays as well as flow cytometry. It is expected that these studies will provide new strategies applicable to the design of clinically relevant mucosal immunization strategies to protect mucosal surfaces.

Research Interests
  • Mucosal immunolgy
  • Immunobiology of the eye
Publications
  • O'Sullivan, N.L. and P.C. Montgomery. 2015. Ocular Mucosal Immunity. In Mucosal Immunology, 4th Ed. eds. J. Mestecky, W. Strober, et al., Elsevier, New York, pp. 1873-1897.
  • Shaw, M.K., Welch, K., Zhao, X., Montgomery, P.C., Thummel, R., and Tse, H.Y. 2014. Identification of two immunogenic T cell epitopes of ApoB-100 and their autoimmune implications. J. Immunol. Cli. Res. 2:1024-1026.
  • O'Sullivan, N.L. and P.C. Montgomery. Ocular Mucosal Immunity. In Mucosal Immunology, 4th Ed. eds. J. Mestecky, W. Strober, et al., Elsevier, invited chapter, in press.
  • Gill, R.F., G. Pirockinaite, N.L. O‚ÄôSullivan and P.C. Montgomery. 2010. Nasal associated lymphoid tissue (NALT) is not an absolute requirement for the induction of rat tear IgA antibody responses. Curr. Eye Res. 35:1-8.
  • O'Sullivan, N.L., A.E. Baylor and P.C. Montgomery. 2007. Development of rat immortalized conjunctival epithelial cell lines. Expt. Eye Res. 84:323-331
  • O'Sullivan, N.L., P.C. Montgomery and D.A. Sullivan. 2005. Ocular Mucosal Immunity. In Mucosal Immunology, 3rd Ed. eds. P.L. Ogra, J. Mestecky, et al., Academic Press, New York. p 1477-1496.
  • Gill R.F. and Montgomery P.C. 2002. Enhancement of rat tear IgA antibody responses following intranasal immunization with antigen and CpG ODN. Curr. Eye Res., 24:228-33. Medline
  • O'Sullivan, N.L., C.A. Skandera and P.C. Montgomery. 2001. Development of T cell lineages in rat lacrimal glands. Curr. Eye Res., 22:375-83. Medline
  • O'Sullivan, N.L., C.A. Skandera and P.C. Montgomery. 2001. Lymphocyte lineages at mucosal effector sites: Rat salivary glands. J. Immunol., 166:5522-5529. Medline
  • Montgomery, P.C. and D.E. Rafferty. 1998. Induction of secretory and serum antibody responses following oral administration of antigen with bioadhesive degradable starch microparticles. Oral Micro. Immunol., 13:139-149. Medline
  • Ridley Lathers, D.M., R.F. Gill and P.C. Montgomery. 1998. Inductive pathways leading to rat tear IgA antibody responses. Invest. Ophthal. Vis. Sci., 39:1005-1011. Medline
  • O'Sullivan, N.L., C.A. Skandera and P.C. Montgomery. 1998. Rat lacrimal glands contain activated and resting mature T cells, recent thymic emigrants and possible extrathymic populations. In Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2, ed. D.A. Sullivan, D.A. Dartt and M.A. Meneray, Plenum, New York, 591-598.
  • Masinick, S.A., C.P. Montgomery, P.C. Montgomery and L.D. Hazlett. 1997. Secretory IgA inhibits Pseudomonas aeruginosa binding to cornea and protects against keratitis. Invest. Ophthal. Vis. Sci., 910-918. Medline
  • Montgomery, P.C. and J. Whittum-Hudson. 1996. Mucosal immunity in the ocular system. In Mucosal Vaccines: New Trends in Immunization, ed. H. Kiyono, P. Ogra and J. McGhee, Academic Press, New York, NY, p 403-423.
  • Carr, R.M., C.M. Lolachi, R.G. Albaran, D.M. Ridley, P.C. Montgomery and N.L. O'Sullivan. 1996. Nasal-associated lymphoid tissue is an inductive site for rat tear IgA antibody responses. Immunol. Invest., 25:387-396. Medline
  • O'Sullivan, N.L., C.A. Skandera and P.C. Montgomery. 1996. The specificity of adhesive interactions between rat lymphocytes and salivary gland epithelia. Cell. Immunol., 169:142-151. Medline
  • Montgomery, P.C., C.A. Skandera and N.L. O'Sullivan. 1996. Phenotypic profiles of lymphcoyte populations isolated from rat major salivary glands. Oral Micro. Immunol., 11:248-253. Medline
  • Rafferty, D.E., M.G. Elfaki and P.C. Montgomery. 1996. Preparation and characterization of a biodegradable microparticle antigen/cytokine delivery system. Vaccine, 14:532-538. Medline
  • O'Sullivan, N.L., R. Raja and P.C. Montgomery. 1995. Lymphocyte adhesive interactions with lacrimal gland acinar epithelial cells in primary culture. Invest. Ophthal. Vis. Sci., 36:2246-2253. Medline
  • Rafferty, D.E. and P.C. Montgomery. 1995. The effects of transforming growth factor-b and interleukins 2, 5 and 6 on immunoglobulin production in cultured rat salivary gland tissues. Oral Micro. Immunol., 10:81-86. Medline
  • Elfaki, M.G., N.L. O'Sullivan, C.A. Skandera and P.C. Montgomery. 1994. Modulation of lymphocyte adhesion to rat salivary gland epithelia by interleukin-4 and transforming growth factor-b. Reg. Immunol., 6: 225-231.

 

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